Metabolic abnormalities associated with obesity increase the risk of cardiovascular disease (CVD), including coronary artery disease and heart failure. Most of the deaths for which overweight is responsible can be related to CVD and T2DM. The underlying mechanisms have not been fully elucidated, but may include metabolic, hemodynamic, and inflammatory effects of having an increased adipose tissue mass.
http://www.onlinejacc.org/content/71/6/670?_ga=2.94406687.2045287205.1536578801-363832027.1536578800